- Title
- In Elimination Settings, Measles Antibodies Wane After Vaccination but Not After Infection: A Systematic Review and Meta-Analysis
- Creator
- Bolotin, Shelly; Osman, Selma; Jardine, Rachel; Faulkner, Maryrose; Hahné, Susan J. M.; Heffernan, Jane M.; Dabbagh, Alya; Rota, Paul A.; Severini, Alberto; Jit, Mark; Durrheim, David N.; Orenstein, Walter A.; Hughes, Stephanie L.; Moss, William J.; Funk, S; Turner, N; Schluter, W; Jawad, JS; Crowcroft, NS; Ariyarajah, Archchun; Tricco, Andrea C.; Khan, Sumaiya; Li, Lennon; Johnson, Caitlin; Friedman, Lindsay; Gul, Nazish
- Relation
- Journal of Infectious Diseases Vol. 226, Issue 7, p. 1127-1139
- Publisher Link
- http://dx.doi.org/10.1093/infdis/jiac039
- Publisher
- Oxford University Press
- Resource Type
- journal article
- Date
- 2022
- Description
- Background: We conducted a systematic review to assess whether measles humoral immunity wanes in previously infected or vaccinated populations in measles elimination settings. Methods: After screening 16 822 citations, we identified 9 articles from populations exposed to wild-type measles and 16 articles from vaccinated populations that met our inclusion criteria. Results: Using linear regression, we found that geometric mean titers (GMTs) decreased significantly in individuals who received 2 doses of measles-containing vaccine (MCV) by 121.8 mIU/mL (95% confidence interval [CI], -212.4 to -31.1) per year since vaccination over 1 to 5 years, 53.7 mIU/mL (95% CI, -95.3 to -12.2) 5 to 10 years, 33.2 mIU/mL (95% CI, -62.6 to -3.9), 10 to 15 years, and 24.1 mIU/mL (95% CI, -51.5 to 3.3) 15 to 20 years since vaccination. Decreases in GMT over time were not significant after 1 dose of MCV or after infection. Decreases in the proportion of seropositive individuals over time were not significant after 1 or 2 doses of MCV or after infection. Conclusions: Measles antibody waning in vaccinated populations should be considered in planning for measles elimination.
- Subject
- measles elimination; measles immunity; measles vaccination; waning immunity
- Identifier
- http://hdl.handle.net/1959.13/1487540
- Identifier
- uon:52174
- Identifier
- ISSN:0022-1899
- Language
- eng
- Reviewed
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